How Tramadol helps in acute pain management?
Acute pain has become one of the most rampant, expensive and disabling conditions in the history of clinical practice and even the workplace, yet remains inadequately treated. There are many causes of joint pain. Musculoskeletal conditions, such as lower-back pain and osteoarthritis (OA), are the leading causes of the disability among the working age-group.
The goals of adequate pain management include relief from pain, minimizing disability, improving a quality of life and preventing progression of the disease. The most favorable administration requires a combination of both nonpharmacological as well as pharmacological modalities of therapy. The pain management procedure and guide¬lines have shifted their magnitude from the usage of NSAIDs and COX-2 inhibitors to opioids, Tramadol Hydrochloride; generic name Tramadol is being the most recommended one of the lot.
What are the ways in which Tramadol acts to ease the acute pain?
Tramadol is generally used in curbing pain, particularly when other analgesics have failed to ease the acute discomfort.
Tramadol offers narcotic-like relief but is not a narcotic; it is a drug that is a “centrally acting synthetic“.
Tramadol functions by binding to the opioid receptors, where it produces morphine-like effects. Its second act is to weakly accelerate the release of serotonin and noradrenaline spinal cord concentrations by reuptake inhibition.
Once ingested by the patient, Tramadol gets rapidly absorbed and metabolized in the liver via cytochrome P450 (CYP) 2D6 and 3A to several metabolites.
The CYP2D6 the only metabolite M1, which happens to have a higher rate of affinity than Tramadol for mu opioid receptors which ultimately makes a significant contribution to the onset of pain relieving action.The pain starts to ease within an hour of ingestion and continues to peak within two hours.
How effective is Tramadol in curbing acute pain?
Tramadol is a safe and quite an effective analgesic in the management of moderate to acute pain in adults at a recommended dosage.
The decision of prescribing Tramadol online prescription to a patient should be purely based on the clinical status of the patient. It should be prescribed only in a situation when other painkillers are considered unsuitable.
The effects of Tramadol are very similar to that of codeine but it is not as effective as morphine.Its specific aspects make effective in cardiac and pediatric surgery.
Although Tramadol is not associated with any sort of clinically relevant respiratory depression, it has its share of side effects in form of nausea, itching, sedation, dyspepsia, emesis, vomiting, drowsiness, dizziness, headache and dry mouth.
When it is compared to other opioids, Tramadol has a lower rate of constipation and also poses a lower risk of long-term addiction. Chronic pain is still far from being a solved problem.
Although Tramadol has proved its value as an effective analgesic drug, it needs further modifications to achieve its full potential in order to emerge as an efficient pain management drug.
An immediate need is to find a suitable stability between the analgesic efficacies and the tolerability in drugs in order to improve patient’s adherence to long-term treatments.